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Histamine Intolerance Debunked


Histamine intolerance, a condition characterized by an inability to properly metabolize histamine, is gaining recognition as a significant player in various health issues. While often associated with


allergic reactions, histamine intolerance can also stem from gut-related problems. In this blog post, we'll delve into the intricacies of histamine intolerance, explore its connection to gut health, and discuss why collagen supplementation may not be advisable for those with this condition. We'll also explore alternative supplements to consider.

*Please note, I am not a medical professional, any questions or concerns should be addressed by your physician, or a licensed professional. *

Unraveling Histamine Intolerance:

Histamine: A Double-Edged Sword: Histamine is a naturally occurring compound in our bodies, playing a crucial role in immune responses, stomach acid regulation, and neurotransmitter functions. However, for individuals with histamine intolerance, the body struggles to break down histamine efficiently, leading to an accumulation of this compound and triggering a range of symptoms.

Gut Health and Histamine Intolerance: The gut plays a pivotal role in histamine regulation. Histamine is metabolized by enzymes produced in the gut lining. When there's an imbalance in the gut microbiota, inflammation, or damage to the gut lining—common factors in conditions like leaky gut syndrome—histamine intolerance can manifest.

Why Collagen Supplementation Might Pose Challenges:

Histamine Content in Collagen: Collagen, a popular supplement for its skin, joint, and gut health benefits, may not be suitable for individuals with histamine intolerance. Collagen itself contains histamine, and while some people may tolerate it well, those with histamine sensitivity may experience an exacerbation of symptoms.

Collagen and Gut Reactions: Additionally, collagen supplements can sometimes cause


digestive discomfort, and for individuals with histamine intolerance, this may further strain an already compromised gut. It's essential to approach collagen supplementation with caution and awareness of individual sensitivities.

Alternative Supplements for Histamine-Intolerant Individuals:

Quercetin: Quercetin is a flavonoid with natural antihistamine properties. Found in various fruits, vegetables, and supplements, quercetin can help stabilize mast cells, which are responsible for histamine release.

Vitamin C: Vitamin C acts as a natural antihistamine and supports the immune system. Incorporating vitamin C-rich foods or supplements can be beneficial for individuals with histamine intolerance.

DAO (Diamine Oxidase) Enzyme: DAO is an enzyme responsible for breaking down histamine in the digestive tract. In some cases of histamine intolerance, individuals may have insufficient DAO production. DAO supplements can be taken before meals to help metabolize ingested histamine.

B Vitamins: B vitamins, particularly B6, B9 (folate), and B12, play a role in histamine metabolism. Ensuring adequate levels of these vitamins through diet or supplementation can support the body in managing histamine.


Understanding histamine intolerance is a crucial step in managing its symptoms and improving overall well-being. While collagen supplementation has gained popularity for its diverse health benefits, individuals with histamine intolerance should approach it with caution due to its histamine content. Instead, exploring alternative supplements that support histamine metabolism and overall gut health can be a more suitable path. As always, consulting with healthcare professionals and registered dietitians is advisable to create a personalized approach to address histamine intolerance and ensure optimal health.

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Hi, I'm Amanda, founder of Damngoodthyme. I'm so glad to have you here!

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